There currently are a variety of options to travel by night train or night bus from Brussels (Belgium) to Prague (Czech Republic), taking between approximately 12 and 17 hours: Namely the ES 453 and the BUS Londýn - Praha. These lines are operated by European Sleeper and Regiojet.

Next offers

European Sleeper is a young Dutch startup connecting several European cities in Belgium, the Netherlands, Germany and the Czech Republic with their "Good Night Train". In the sleeper cars, you can book lockable single, double or triple compartments, all with their own washbasin. Bedding, toiletries, towels and breakfast are included. Compartments can be locked from the inside. Choose between standard couchette cars with 6 berths or air-conditioned comfort couchettes for 5 people. The latter can be booked privately or exclusively for women. Blankets, bedding and mineral water are included, breakfast can be added for an additional fee. Compartments can be locked from the inside. As the most economical option, seating cars with 6-person compartments are available. Seat reservations are included in the price. Drinks and snacks can be purchased from the train crew.

Regiojet operates both night trains and night buses across Europe, providing various travel options. Their night trains feature several types of cabins, including seats that can recline slightly for added comfort, as well as private sleeping couchettes that accommodate one to four passengers, equipped with bedding and duvets. Wifi is available and breakfast and coffee are complimentary. Regiojet night buses feature ergonomic seating that can recline for comfort, with generous legroom and amenities such as USB charging ports, free WiFi, personal entertainment screens, and complimentary refreshments available during the journey. There is also a toilet on the bus.

For the next 7 dates with connections, the cheapest offer starts at 50 EUR. Check our connection pages below for all availabilities!

Offers on the date of your choice

Next available offers

Wed, 14.05.2025

from 110 EUR

Thu, 15.05.2025

from 50 EUR

Fri, 16.05.2025

from 100 EUR

Sun, 18.05.2025

from 57 EUR

Mon, 19.05.2025

from 80 EUR

Wed, 21.05.2025

from 90 EUR

Thu, 22.05.2025

from 50 EUR