There currently are a variety of options to travel by night bus or night train from Prague (Czech Republic) to Brussels (Belgium), taking between approximately 12 and 16 hours: Namely the BUS Praha - Londýn and the ES 452. These lines are operated by Regiojet and European Sleeper.

Next offers

Regiojet operates both night trains and night buses across Europe, providing various travel options. Regiojet night trains offer a range of cabin options, from standard reclining seats in open compartments to private couchette cabins designed for one to four travelers, complete with bedding and duvets for a restful journey. Wifi is available and breakfast and coffee are served for free. The night buses are designed with comfortable, spacious seats that recline, providing ample legroom. Each bus is equipped with individual power outlets, free hot drings, free WiFi, and onboard entertainment systems to enhance the travel experience. Buses also feature a toilet.

European Sleeper is a young Dutch startup connecting several European cities in Belgium, the Netherlands, Germany and the Czech Republic with their "Good Night Train". The sleeper cars offer comfortable and lockable compartments for one, two or three persons, each equipped with a washbasin. The service includes bedding, towels, toiletries and breakfast. A wake-up service is available. The couchette cars come in two variants: standard (6 people) and comfort (5 people, air-conditioned). Both include bedding, blankets and pillows. Comfort compartments can be booked as private or women-only compartments. The compartments can be locked from the inside. As the most economical option, seating cars with 6-person compartments are available. Seat reservations are included in the price. Drinks and snacks can be purchased from the train crew.

For the next 7 dates with connections, the cheapest offer starts at 61 EUR. Check our connection pages below for all availabilities!

Offers on the date of your choice

Next available offers

Tue, 22.07.2025

from 81 EUR

Thu, 24.07.2025

from 150 EUR

Fri, 25.07.2025

from 61 EUR

Sun, 27.07.2025

from 120 EUR

Tue, 29.07.2025

from 61 EUR

Thu, 31.07.2025

from 120 EUR

Fri, 01.08.2025

from 61 EUR