There currently are a variety of options to travel by night bus or night train from Frankfurt am Main (Germany) to Prague (Czech Republic), taking between approximately 6 and 9 hours: Namely the BUS Amsterdam - Praha and the EN 40459. These lines are operated by Regiojet and ÖBB.
Regiojet operates both night trains and night buses across Europe, providing various travel options. Their night trains feature several types of cabins, including seats that can recline slightly for added comfort, as well as private sleeping couchettes that accommodate one to four passengers, equipped with bedding and duvets. Wifi is available and breakfast and coffee are complimentary. The night buses are designed with comfortable, spacious seats that recline, providing ample legroom. Each bus is equipped with individual power outlets, free hot drings, free WiFi, and onboard entertainment systems to enhance the travel experience. Buses also feature a toilet.
The Austrian Federal Railways (ÖBB) operate the Nightjet and Euronight trains (the latter together with other national railway agencies). The ÖBB usually offer three types of carriages in their night trains: seats, couchettes, and sleepers. Seats are for the bravest, while couchettes and sleepers provide a more comfortable journey. Couchettes can hold up to six people, whereas sleepers are private compartments for one to three people. They sometimes include a private bathroom or even a shower, sometimes only a sink.
For the next 7 dates with connections, the cheapest offer starts at 25 EUR. Check our connection pages below for all availabilities!