There currently is one option to travel by night bus from London (United Kingdom) to Prague (Czech Republic), taking approximately 18 hours: Namely the BUS Londýn - Praha operated by Regiojet.
Regiojet operates both night trains and night buses across Europe, providing various travel options. Regiojet night trains offer a range of cabin options, from standard reclining seats in open compartments to private couchette cabins designed for one to four travelers, complete with bedding and duvets for a restful journey. Wifi is available and breakfast and coffee are served for free. Regiojet night buses feature ergonomic seating that can recline for comfort, with generous legroom and amenities such as USB charging ports, free WiFi, personal entertainment screens, and complimentary refreshments available during the journey. There is also a toilet on the bus.
For the next 7 dates with connections, the cheapest offer starts at 36 EUR. Check our connection pages below for all availabilities!